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Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary

Sections were stained with Masson trichrome

Research using orthotopic mouse models has shown that chemotherapy can induce reprogramming of TAMs toward a more pro-inflammatory, anti-tumor profile, which may enhance therapeutic efficacy and suppress chemoresistance [151]

Additionally, supplementing limiting amino acids in plant-based feeds (e.g., lysine, methionine, threonine) enables a reduction in fishmeal use, contributing to marine conservation and lowering feed costs [21, 22, 102]